Page under construction. Please check back later

1. Discovery of novel antibacterial lead compounds targeting bacterial topoisomerase I

Leads for novel antibiotics are urgently needed to combat bacterial pathogens resistant to current treatment. Enzyme based and cell based high throughput screening (HTS) assays are being developed and utilized to identify inhibitors that can act on bacterial topoisomerase I as mode of action. Hit compounds from HTS are being analyzed for SAR.